A number of 2-[3-ethyl-5-oxo-4-(2-phenoxyethyl)-4,5-dihydro-1H-1,2,4-triazol-1-yl]- N-phenylacetamide derivatives KJSSCDG01-10 were produced through the reaction of [3- ethyl-5-oxo-4-(2-phenoxyethyl)-4,5-dihydro-1H-1,2,4-triazol-1-yl] acetic acid 2 with substituted aniline 1a-1j. Their structures were determined to be correct using techniques such as 1H NMR, 13C NMR, MS, IR, and elemental studies. The antibacterial and antifungal properties of all the components have been investigated. Using the cup plate method, the compounds were found to be highly effective against gram-positive (S. aureus) and gram negative (E. coli) bacteria, as well as the fungus A. niger.