We have developed a mobile phone microscope and an imaging chip for detecting sickle cell disease at the point of care. We have also optimized the concentration of a chemical oxygen scavenger (sodium metabisulphite) inside the chip to achieve rapid and controllable sickling of RBCs. In addition to identifying individuals with sickle (HbS) hemoglobin, we could distinguish between sickle cell trait and sickle cell disease based on cell shapes